If you often start X-Plane with the same combination of profiles for Scenery, Plugins, X-Plane preferences and Aircraft it might be quicker to create a QuickStart shortcut.
With the QuickStart shortcut you tell XO to start, select the profiles, start X-Plane and close itself. Of course you can skip profiles too (set to ‘do nothing’), for instance if you don’t use the X-Plane preferences module.